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KMID : 0376219760130010015
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Chonnam Medical Journal
1976 Volume.13 No. 1 p.15 ~ p.23
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Drug Resistance and Distribution of A Factors in Escherichia coli Isolated In Chonnam Area
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Abstract
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Two hundred and fifty-one strains of Escherichia coli isolated from the faeces of out-patients of hospital and healthy persons in Chonnam area in 1971 were examined for their drug resistance and the distribution of R factors.
Of 251 strains isolated, 102(40.6%) were resistant to one or more of the drugs tested, and 66.2% of these resistant strains were multiply resistant. The most frequently found resistance to each drug was ampicillin(AP; 34.%), folowed by tetracycline(TC; 25.5%), colistin(CO.; 20.7%), chloramphenicol (CP; 19.5%), streptomycin(SM; 12.0%), kanamycin (KM; 1.2%) and nalidixic
Qf these 102 resistant strains, 52 strains(50.9%) carried R factors that. were transferable by the usual mixed cultivation. The multiply resistant donor cells transferred R factors into the sensitive recipient cell, Escherichia coli K-12 F- in 66.2%, while singly resistant donor cells in 16. 1%.
Of 12 resistant patterns demonstrated those encountered above 10% were AP, TC AP, TC CP AP, and SM TC CP AP.
Of 14 different kinds of R factors such as (KM)^(r), ,(SM)^(r), (TC)^(r), (CP)^(r),
(AP)^(r), (TC CP^(r), (TC AP)^(r), (CP AP)r^(r), (SM TC)^(r), (SM AP)^(r), (TC CP AP)^(r), (SM TC CP)^(r), (SM TC AP)^(r), and (SM CP AP)^(r), the most common pattern
(SM TC CP)^(r)
The greater the multiplicity of resistance, the greater was the likelihoodthat part or 41 of the resistance markers would be transferable.
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